Remdesivir Rna Polymerase

Rdv is a nucleotide analog inhibitor of rna dependent rna polymerases rdrps. Remdesivir rdv gs 5734 is a monophosphoramidate prodrug of an adenosine analog with potent activity against an array of rna virus families including filoviridae paramyxoviridae pneumoviridae and orthocoronavirinae through the targeting of the viral rna dependent rna polymerase rdrp. Remdesivir inhibits the polymerase enzyme of a number of rna viruses.

Remdesivir binds to the viral rna dependent rna polymerase inhibiting viral replication through premature termination of rna transcription.

Remdesivir rna polymerase. Remdesivir was reported by world health organization who as the most promising drug currently available for the treatment of covid 19. Remdesivir rdv is an investigational compound with a broad spectrum of antiviral activities against rna viruses including severe acute respiratory syndrome cov and middle east respiratory syndrome mers cov. 110 106 hence remdesivir is classified as a direct acting antiviral agent that works as a delayed chain terminator. Rdv is a nucleotide analog inhibitor of rna dependent rna polymerases rdrps.

Ribavirin remdesivir sofosbuvir galidesivir and tenofovir against sars cov 2 rna dependent rna polymerase rdrp. Remdesivir rdv is an investigational compound with a broad spectrum of antiviral activities against rna viruses including sars cov and middle east respiratory syndrome mers cov. This halts genome replication. A molecular docking study author links open overlay panel abdo a.

Using polymerase enzymes from the coronavirus that causes mers scientists in goettes lab found that the enzymes can incorporate remdesivir which resembles an rna building block into new rna strands. Remdesivir is a direct acting antiviral that inhibits rna dependent rna polymerase from severe acute respiratory syndrome coronavirus 2 with high potency j biol chem. Remdesivir is an intravenous iv investigational nucleotide prodrug of an adenosine analog. Shortly after adding remdesivir the enzyme stops being able to add more rna subunits.

For the rna dependent rna polymerase of mers cov sars cov 1 and sars cov 2 arrest of rna synthesis occurs after incorporation of three additional nucleotides. Polymerase enzymes are responsible for synthesizing the rna that is essential to form new viruses so if a drug can inhibit the polymerase of a particular virus it should shut down the replication process figure 1. Here we use molecular dynamics simulations and free energy perturbation methods to study the inhibition mechanism of remdesivir to its target sars cov 2 virus rna dependent rna polymerase rdrp.